What the test looks for
Detection of codon 600 mutations of the BRAF gene (mainly V600E and V600K).
In melanoma, a V600 mutation gives access to combined BRAF and MEK inhibitors. In metastatic colorectal cancer, the V600E mutation has prognostic value and points to a specific targeted treatment. In lung cancer, it is one of the alterations to test for at diagnosis.
Required sample
- FFPE block or unstained slides with one H&E slide (primary tumour or metastasis).
- Tumour cellularity of at least 20% recommended.
- Pathology report enclosed.