What the test looks for
Detection of HER2 (ERBB2) gene amplification by fluorescence in situ hybridisation (FISH), with calculation of the HER2/CEP17 ratio and the mean copy number per nucleus.
Interpretation follows current international guidelines (ASCO/CAP). Amplification makes the patient eligible for anti-HER2 treatments.
Required sample
- FFPE tumour block.
- Fixation in 10% buffered formalin for 6 to 72 hours.
- Pathology report with the HER2 immunohistochemistry score.