What the test looks for
Determination of microsatellite instability status by multiplex PCR on a panel of mononucleotide markers.
A high MSI status (MSI-H) points to Lynch syndrome, to be confirmed in an oncogenetics consultation, and predicts a good response to immunotherapy. The test usefully complements immunohistochemistry of the MMR proteins (MLH1, MSH2, MSH6, PMS2).
Required sample
- FFPE tumour block.
- Tumour cellularity of at least 20%.
- Pathology report enclosed, with the MMR immunohistochemistry result if available.